Neocortical cholinergic pathology after neonatal brain injury is increased by Alzheimer's disease-related genes in mice

Neocortical cholinergic pathology after neonatal brain injury is increased by Alzheimer's disease-related genes in mice

Hypoxic-ischemic encephalopathy (HIE) in neonates causes mortality and neurologic morbidity, including poor cognition with a complex neuropathology. Injury to the cholinergic basal forebrain and its rich innervation of cerebral cortex may also drive cognitive pathology. It is uncertain whether genes...

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Bibliographic Details
Main Authors: Leslie Doucette, Victoria Turnbill, Katherine Carlin, Andrew Cavanagh, Benjamin Sollinger, Nazli Kuter, Debra L. Flock, Shenandoah Robinson, Raul Chavez-Valdez, Lauren Jantzie, Lee J. Martin, Frances J. Northington
Format: Article
Language:English
Published: Elsevier 2024-10-01
Series:Neurobiology of Disease
Subjects:
Amyloid, Cholinergic Cortical innervation
Hypoxic-ischemic encephalopathy
Entorhinal cortex
Interneurons
Somato-dendritic attrition
Axonal and neuritic pathology
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996124002298

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http://www.sciencedirect.com/science/article/pii/S0969996124002298

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