The P. falciparum alternative histones Pf H2A.Z and Pf H2B.Z are dynamically acetylated and antagonized by PfSir2 histone deacetylases at heterochromatin boundaries

The P. falciparum alternative histones Pf H2A.Z and Pf H2B.Z are dynamically acetylated and antagonized by PfSir2 histone deacetylases at heterochromatin boundaries

ABSTRACTThe Plasmodium falciparum alternative histones Pf H2A.Z and Pf H2B.Z are enriched in the same nucleosomes in intergenic euchromatin but depleted from heterochromatin. They occupy most promoters but are only dynamically associated with expression at var genes. In other organisms, acetylation...

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Bibliographic Details
Main Authors: Suffian Azizan, Shamista A. Selvarajah, Jingyi Tang, Myriam D. Jeninga, Danae Schulz, Kapil Pareek, Tamara Herr, Karen P. Day, Tania F. De Koning-Ward, Michaela Petter, Michael F. Duffy
Format: Article
Language:English
Published: American Society for Microbiology 2023-12-01
Series:mBio
Subjects:
malaria
variant histones
chromatin
epigenetics
regulation of gene expression
Online Access:https://journals.asm.org/doi/10.1128/mbio.02014-23

Internet

https://journals.asm.org/doi/10.1128/mbio.02014-23

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