Oxidative Stress in Canine Histiocytic Sarcoma Cells Induced by an Infection with Canine Distemper Virus Led to a Dysregulation of HIF-1α Downstream Pathway Resulting in a Reduced Expression of VEGF-B In Vitro

Oxidative Stress in Canine Histiocytic Sarcoma Cells Induced by an Infection with Canine Distemper Virus Led to a Dysregulation of HIF-1α Downstream Pathway Resulting in a Reduced Expression of VEGF-B In Vitro

Histiocytic sarcomas represent malignant tumors which require new treatment strategies. Canine distemper virus (CDV) is a promising candidate due to its oncolytic features reported in a canine histiocytic sarcoma cell line (DH82 cells). Interestingly, the underlying mechanism might include a dysregu...

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Bibliographic Details
Main Authors: Federico Armando, Matteo Gambini, Attilio Corradi, Chiara Giudice, Vanessa Maria Pfankuche, Graham Brogden, Friederike Attig, Maren von Köckritz-Blickwede, Wolfgang Baumgärtner, Christina Puff
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Viruses
Subjects:
angiogenesis
canine distemper virus
canine histiocytic sarcoma
dh82
hif-1α
oxidative stress
vegf-b
viral oncolysis
Online Access:https://www.mdpi.com/1999-4915/12/2/200

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https://www.mdpi.com/1999-4915/12/2/200

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