Protein-responsive protein release of supramolecular/polymer hydrogel composite integrating enzyme activation systems

Responsive hydrogels are of interest for diagnostic and controlled drug release applications. Here, the authors report on the design of a hydrogel with protein triggered release of an embedded protein through recovery of enzyme activity and subsequent degradation of supramolecular fibers.

Bibliographic Details
Main Authors: Hajime Shigemitsu, Ryou Kubota, Keisuke Nakamura, Tomonobu Matsuzaki, Saori Minami, Takuma Aoyama, Kenji Urayama, Itaru Hamachi
Format: Article
Language:English
Published: Nature Portfolio 2020-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-17698-0