Mitophagy-Mediated mtDNA Release Aggravates Stretching-Induced Inflammation and Lung Epithelial Cell Injury via the TLR9/MyD88/NF-κB Pathway

Mitophagy-Mediated mtDNA Release Aggravates Stretching-Induced Inflammation and Lung Epithelial Cell Injury via the TLR9/MyD88/NF-κB Pathway

BackgroundIn animal models of ventilation-induced lung injury, mitophagy triggers mitochondria damage and the release of mitochondrial (mt) DNA, which activates inflammation. However, the mechanism of this process is unclear.MethodsA model of cyclic stretching (CS)-induced lung epithelial cell injur...

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Bibliographic Details
Main Authors: Ren Jing, Zhao-Kun Hu, Fei Lin, Sheng He, Sui-Sui Zhang, Wan-Yun Ge, Hui-jun Dai, Xue-Ke Du, Jin-Yuan Lin, Ling-Hui Pan
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
mitophagy
mitochondrial DNA
Toll-like receptor 9
mechanical stretching
lung injury
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00819/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.00819/full

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