Melatonin sensitises shikonin-induced cancer cell death mediated by oxidative stress via inhibition of the SIRT3/SOD2-AKT pathway

Melatonin sensitises shikonin-induced cancer cell death mediated by oxidative stress via inhibition of the SIRT3/SOD2-AKT pathway

Recent research suggests that melatonin (Mel), an endogenous hormone and natural supplement, possesses anti-proliferative effects and can sensitise cells to anti-cancer therapies. Although shikonin (SHK) also possesses potential anti-cancer properties, the poor solubility and severe systemic toxicit...

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Bibliographic Details
Main Authors: Mengling Li, Chengai Wu, Jibran Sualeh Muhammad, Dan Yan, Koichi Tsuneyama, Hideki Hatta, Zheng-Guo Cui, Hidekuni Inadera
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Redox Biology
Subjects:
Melatonin
SIRT3/SOD2
Apoptosis
Reactive oxygen species
AKT
Shikonin
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720308375

Internet

http://www.sciencedirect.com/science/article/pii/S2213231720308375

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