Improving detection of JC virus by ultrafiltration of cerebrospinal fluid before polymerase chain reaction for the diagnosis of progressive multifocal leukoencephalopathy

Improving detection of JC virus by ultrafiltration of cerebrospinal fluid before polymerase chain reaction for the diagnosis of progressive multifocal leukoencephalopathy

Abstract Background Progressive multifocal leukoencephalopathy (PML) is a demyelinating disorder caused by JC virus (JCV). Although detecting JCV DNA in the cerebrospinal fluid (CSF) by real-time polymerase chain reaction (PCR) is useful, diagnosis is difficult when JCV concentrations are low. We th...

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Bibliographic Details
Main Authors: Kazuo Nakamichi, Michi Kawamoto, Junko Ishii, Masayuki Saijo
Format: Article
Language:English
Published: BMC 2019-10-01
Series:BMC Neurology
Subjects:
Cerebrospinal fluid
JC virus
Progressive multifocal leukoencephalopathy
Real-time PCR testing
Ultrafiltration
Online Access:http://link.springer.com/article/10.1186/s12883-019-1476-2

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http://link.springer.com/article/10.1186/s12883-019-1476-2

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