From frozen cell bank to product assay: high-throughput strain characterisation for autonomous Design-Build-Test-Learn cycles

From frozen cell bank to product assay: high-throughput strain characterisation for autonomous Design-Build-Test-Learn cycles

Abstract Background Modern genome editing enables rapid construction of genetic variants, which are further developed in Design-Build-Test-Learn cycles. To operate such cycles in high throughput, fully automated screening, including cultivation and analytics, is crucial in the Test phase. Here, we p...

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Bibliographic Details
Main Authors: Laura M. Helleckes, Debora Puchta, Hannah Czech, Holger Morschett, Bertram Geinitz, Wolfgang Wiechert, Marco Oldiges
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Microbial Cell Factories
Subjects:
Bioprocess development
Automation
Microbioreactor
Clean-in-place
Design-Build-Test-Learn
Online Access:https://doi.org/10.1186/s12934-023-02140-z

Internet

https://doi.org/10.1186/s12934-023-02140-z

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