Influence of apocynin on cardiac remodeling in rats with streptozotocin-induced diabetes mellitus

Influence of apocynin on cardiac remodeling in rats with streptozotocin-induced diabetes mellitus

Abstract Background Increased reactive oxygen species (ROS) generation in diabetes mellitus (DM) is an important mechanism leading to diabetic cardiomyopathy. Apocynin, a drug isolated from the herb Picrorhiza kurroa, is considered an antioxidant agent by inhibiting NADPH oxidase activity and improv...

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Main Authors: R. Gimenes, C. Gimenes, C. M. Rosa, N. P. Xavier, D. H. S. Campos, A. A. H. Fernandes, M. D. M. Cezar, G. N. Guirado, L. U. Pagan, I. D. Chaer, D. C. Fernandes, F. R. Laurindo, A. C. Cicogna, M. P. Okoshi, K. Okoshi
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Cardiovascular Diabetology
Subjects:
Diabetic cardiomyopathy
Heart failure
Oxidative stress
NADPH oxidase
NADPH oxidase blocker
Echocardiogram
Online Access:http://link.springer.com/article/10.1186/s12933-017-0657-9

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http://link.springer.com/article/10.1186/s12933-017-0657-9

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