N-Methyl D-aspartate receptor subtype 2B/Ca2+/calmodulin-dependent protein kinase II signaling in the lateral habenula regulates orofacial allodynia and anxiety-like behaviors in a mouse model of trigeminal neuralgia

N-Methyl D-aspartate receptor subtype 2B/Ca2+/calmodulin-dependent protein kinase II signaling in the lateral habenula regulates orofacial allodynia and anxiety-like behaviors in a mouse model of trigeminal neuralgia

Trigeminal neuralgia (TN) is a peripheral nerve disorder often accompanied by abnormalities in mood. The lateral habenula (LHb) plays important roles in the modulation of pain and emotion. In the present study, we investigated the involvement of the LHb in the mechanisms underlying allodynia and anx...

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Bibliographic Details
Main Authors: Zi-Fan Zhuang, Hong-Yun Wu, Ya-Yi Song, Lei Li, Xia Cui, Jie Yang, Xiang-Qing Xu, Wen-Qiang Cui
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Cellular Neuroscience
Subjects:
trigeminal neuralgia
anxiety
lateral habenula
Ca2+/calmodulin-dependent protein kinase II (CaMKII)
N-methyl-D-aspartate receptor (NMDAr)
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2022.981190/full

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https://www.frontiersin.org/articles/10.3389/fncel.2022.981190/full

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