An Lmx1b-miR135a2 regulatory circuit modulates Wnt1/Wnt signaling and determines the size of the midbrain dopaminergic progenitor pool.

An Lmx1b-miR135a2 regulatory circuit modulates Wnt1/Wnt signaling and determines the size of the midbrain dopaminergic progenitor pool.

MicroRNAs regulate gene expression in diverse physiological scenarios. Their role in the control of morphogen related signaling pathways has been less studied, particularly in the context of embryonic Central Nervous System (CNS) development. Here, we uncover a role for microRNAs in limiting the spa...

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Bibliographic Details
Main Authors: Angela Anderegg, Hsin-Pin Lin, Jun-An Chen, Giuliana Caronia-Brown, Natalya Cherepanova, Beth Yun, Milan Joksimovic, Jason Rock, Brian D Harfe, Randy Johnson, Rajeshwar Awatramani
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3861205?pdf=render

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http://europepmc.org/articles/PMC3861205?pdf=render

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