FTO-mediated m <sup>6</sup>A demethylation of ULK1 mRNA promotes autophagy and activation of hepatic stellate cells in liver fibrosis

FTO-mediated m <sup>6</sup>A demethylation of ULK1 mRNA promotes autophagy and activation of hepatic stellate cells in liver fibrosis

The activation of hepatic stellate cells (HSCs) is central to the occurrence and development of liver fibrosis. Our previous studies showed that autophagy promotes HSC activation and ultimately accelerates liver fibrosis. Unc-51-like autophagy activating kinase 1 (ULK1) is an autophagic initiator in...

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Bibliographic Details
Main Authors: Huang Tingjuan, Zhang Chunhong, Ren Junjie, Shuai Qizhi, Li Xiaonan, Li Xuewei, Xie Jun, Xu Jun
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2024-08-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
autophagy
hepatic stellate cells
FTO
m <sup>6</sup>A methylation
ULK1
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2024098

Internet

https://www.sciengine.com/doi/10.3724/abbs.2024098

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