Senolytic Flavonoids Enhance Type-I and Type-II Cell Death in Human Radioresistant Colon Cancer Cells through AMPK/MAPK Pathway

Senolytic Flavonoids Enhance Type-I and Type-II Cell Death in Human Radioresistant Colon Cancer Cells through AMPK/MAPK Pathway

Resistance to cancer therapies remains a clinical challenge and an unsolved problem. In a previous study, we characterized a new colon cancer cell line, namely HT500, derived from human HT29 cells and resistant to clinically relevant levels of ionizing radiation (IR). Here, we explored the effects o...

Full description

Bibliographic Details
Main Authors: Maria Russo, Stefania Moccia, Diomira Luongo, Gian Luigi Russo
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Cancers
Subjects:
radioresistance
autophagy
SASP
natural senolytics
AMPK
ERKs kinases
Online Access:https://www.mdpi.com/2072-6694/15/9/2660

Internet

https://www.mdpi.com/2072-6694/15/9/2660

Similar Items