The Role of DNA Repair in Immunological Diversity: From Molecular Mechanisms to Clinical Ramifications

The Role of DNA Repair in Immunological Diversity: From Molecular Mechanisms to Clinical Ramifications

An effective humoral immune response necessitates the generation of diverse and high-affinity antibodies to neutralize pathogens and their products. To generate this assorted immune repertoire, DNA damage is introduced at specific regions of the genome. Purposeful genotoxic insults are needed for th...

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Bibliographic Details
Main Authors: Peter Gullickson, Yunwen W. Xu, Laura J. Niedernhofer, Elizabeth L. Thompson, Matthew J. Yousefzadeh
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Immunology
Subjects:
immunological diversity
immunodeficiency
antibodies
DNA damage
DNA repair
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.834889/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.834889/full

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