The Role of DNA Repair in Immunological Diversity: From Molecular Mechanisms to Clinical Ramifications
An effective humoral immune response necessitates the generation of diverse and high-affinity antibodies to neutralize pathogens and their products. To generate this assorted immune repertoire, DNA damage is introduced at specific regions of the genome. Purposeful genotoxic insults are needed for th...
Main Authors: | Peter Gullickson, Yunwen W. Xu, Laura J. Niedernhofer, Elizabeth L. Thompson, Matthew J. Yousefzadeh |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2022-04-01
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Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.834889/full |
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