Adenosine A2A Receptor Stimulation Inhibits TCR-Induced Notch1 Activation in CD8+T-Cells

Adenosine A2A Receptor Stimulation Inhibits TCR-Induced Notch1 Activation in CD8+T-Cells

Notch receptors signaling is required for optimal T-cell activation and function. T-cell receptor (TCR) engagement can activate Notch receptors in T-cells in a ligand-independent fashion. In this study, we examined the role of adenosine A2A receptor (A2AR) signaling pathway in regulating the activit...

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Bibliographic Details
Main Authors: Claudia Sorrentino, Fokhrul Hossain, Paulo C. Rodriguez, Rosa A. Sierra, Antonio Pannuti, Stephen Hatfield, Barbara A. Osborne, Lisa M. Minter, Lucio Miele, Silvana Morello
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Immunology
Subjects:
adenosine
A2A adenosine receptor (A2AR)
Notch1
CD8+T-cells
immunosuppression
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00162/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00162/full

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