Zika virus vertical transmission in interferon receptor1-antagonized Rag1 −/− mice results in postnatal brain abnormalities and clinical disease

Zika virus vertical transmission in interferon receptor1-antagonized Rag1 −/− mice results in postnatal brain abnormalities and clinical disease

Abstract The mechanisms by which vertically transmitted Zika virus (ZIKV) causes postnatal brain development abnormalities and congenital disease remain poorly understood. Here, we optimized the established anti-IFNAR1 treated, Rag1 −/− (AIR) mouse model of ZIKV infection to examine the consequence...

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Bibliographic Details
Main Authors: Clayton W. Winkler, Chad S. Clancy, Rebecca Rosenke, Karin E. Peterson
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Acta Neuropathologica Communications
Subjects:
Zika virus
Pathogenesis
Postnatal infection
Congenital brain abnormalities
Cell death
Cerebellar progenitor proliferation
Online Access:https://doi.org/10.1186/s40478-022-01351-6

Internet

https://doi.org/10.1186/s40478-022-01351-6

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