Zika virus vertical transmission in interferon receptor1-antagonized Rag1 −/− mice results in postnatal brain abnormalities and clinical disease
Abstract The mechanisms by which vertically transmitted Zika virus (ZIKV) causes postnatal brain development abnormalities and congenital disease remain poorly understood. Here, we optimized the established anti-IFNAR1 treated, Rag1 −/− (AIR) mouse model of ZIKV infection to examine the consequence...
Main Authors: | , , , |
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Format: | Article |
Language: | English |
Published: |
BMC
2022-04-01
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Series: | Acta Neuropathologica Communications |
Subjects: | |
Online Access: | https://doi.org/10.1186/s40478-022-01351-6 |