Oligosaccharide Chromatographic Techniques for Quantitation of Structural Process-Related Impurities in Heparin Resulting From 2-O Desulfation

Oligosaccharide Chromatographic Techniques for Quantitation of Structural Process-Related Impurities in Heparin Resulting From 2-O Desulfation

Heparin is a widely-used intravenous anticoagulant comprising a complex mixture of highly-sulfated linear polysaccharides of repeating sequences of uronic acids (either iduronic or glucuronic) 1->4 linked to D-glucosamine with specific sulfation patterns. Preparation of crude heparin from mam...

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Bibliographic Details
Main Authors: Pascal Anger, Céline Martinez, Pierre Mourier, Christian Viskov
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Medicine
Subjects:
heparin
process
desulfation
impurities
pharmacopeias
chromatography
Online Access:https://www.frontiersin.org/article/10.3389/fmed.2018.00346/full

Internet

https://www.frontiersin.org/article/10.3389/fmed.2018.00346/full

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