CCL2-Mediated Stromal Interactions Drive Macrophage Polarization to Increase Breast Tumorigenesis

CCL2-Mediated Stromal Interactions Drive Macrophage Polarization to Increase Breast Tumorigenesis

CCL2 is an inflammatory cytokine that regulates macrophage activity and is implicated in increased mammographic density and early breast tumorigenesis. The role of CCL2 in mediating stromal interactions that contribute to breast tumorigenesis has yet to be fully elucidated. THP-1-derived macrophages...

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Bibliographic Details
Main Authors: Maddison Archer, Sarah M. Bernhardt, Leigh J. Hodson, Lucy Woolford, Mark Van der Hoek, Pallave Dasari, Andreas Evdokiou, Wendy V. Ingman
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:International Journal of Molecular Sciences
Subjects:
mammographic density
breast tumorigenesis
immune signalling
inflammation
fibroblasts
macrophages
Online Access:https://www.mdpi.com/1422-0067/24/8/7385

Internet

https://www.mdpi.com/1422-0067/24/8/7385

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