Hypoxia-Induced Centrosome Amplification Underlies Aggressive Disease Course in HPV-Negative Oropharyngeal Squamous Cell Carcinomas

Hypoxia-Induced Centrosome Amplification Underlies Aggressive Disease Course in HPV-Negative Oropharyngeal Squamous Cell Carcinomas

Human papillomavirus-negative (HPV-neg) oropharyngeal squamous cell carcinomas (OPSCCs) are associated with poorer overall survival (OS) compared with HPV-positive (HPV-pos) OPSCCs. The major obstacle in improving outcomes of HPV-neg patients is the lack of robust biomarkers and therapeutic targets....

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Bibliographic Details
Main Authors: Karuna Mittal, Da Hoon Choi, Guanhao Wei, Jaspreet Kaur, Sergey Klimov, Komal Arora, Christopher C. Griffith, Mukesh Kumar, Precious Imhansi-Jacob, Brian D. Melton, Sonal Bhimji-Pattni, Remus M. Osan, Padmashree Rida, Paweł Golusinski, Ritu Aneja
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Cancers
Subjects:
hypoxia
human papillomavirus
oropharyngeal squamous cell carcinoma
centrosome amplification
mirna
Online Access:https://www.mdpi.com/2072-6694/12/2/517

Internet

https://www.mdpi.com/2072-6694/12/2/517

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