Thioredoxin-interacting protein-activated intracellular potassium deprivation mediates the anti-tumour effect of a novel histone acetylation inhibitor HL23, a fangchinoline derivative, in human hepatocellular carcinoma

Thioredoxin-interacting protein-activated intracellular potassium deprivation mediates the anti-tumour effect of a novel histone acetylation inhibitor HL23, a fangchinoline derivative, in human hepatocellular carcinoma

Introduction: Hyperactivated histone deacetylases (HDACs) act as epigenetic repressors on gene transcription and are frequently observed in human hepatocellular carcinoma (HCC). Although multiple pharmacological HDAC inhibitors (HDACis) have been developed, none is available in human HCC. Objectives...

Full description

Bibliographic Details
Main Authors: Yuanjun Lu, Yazhou Liu, Junjie Lan, Yau-Tuen Chan, Zixin Feng, Lan Huang, Ning Wang, Weidong Pan, Yibin Feng
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Journal of Advanced Research
Subjects:
HDAC
TXNIP
Potassium deprivation
Sorafenib
Hepatocellular carcinoma
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123222002466

Internet

http://www.sciencedirect.com/science/article/pii/S2090123222002466

Similar Items