Differential Aspartate Usage Identifies a Subset of Cancer Cells Particularly Dependent on OGDH

Differential Aspartate Usage Identifies a Subset of Cancer Cells Particularly Dependent on OGDH

Although aberrant metabolism in tumors has been well described, the identification of cancer subsets with particular metabolic vulnerabilities has remained challenging. Here, we conducted an siRNA screen focusing on enzymes involved in the tricarboxylic acid (TCA) cycle and uncovered a striking rang...

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Bibliographic Details
Main Authors: Eric L. Allen, Danielle B. Ulanet, David Pirman, Christopher E. Mahoney, John Coco, Yaguang Si, Ying Chen, Lingling Huang, Jinmin Ren, Sung Choe, Michelle F. Clasquin, Erin Artin, Zi Peng Fan, Giovanni Cianchetta, Joshua Murtie, Marion Dorsch, Shengfang Jin, Gromoslaw A. Smolen
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Cell Reports
Subjects:
alpha-ketoglutarate dehydrogenase
oxoglutarate dehydrogenase
OGDH
citric acid cycle
TCA cycle
Krebs cycle
malate-aspartate shuttle
aspartate
cancer metabolism
target validation
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716312918

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http://www.sciencedirect.com/science/article/pii/S2211124716312918

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