Dasiglucagon Effects on QTc in Healthy Volunteers: A Randomized, Placebo-Controlled, Dose-Escalation, Double-Blind Study

Dasiglucagon Effects on QTc in Healthy Volunteers: A Randomized, Placebo-Controlled, Dose-Escalation, Double-Blind Study

ABSTRACT: Background: Dasiglucagon is a novel glucagon analog that is stable in aqueous formulation and approved for use in severe hypoglycemia. Concentration-QTc analyses are critical for assessing risk of drug-induced QTc prolongation and potential for fatal cardiac arrhythmias such as torsades d...

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Bibliographic Details
Main Authors: Ramin Tehranchi, MD, PhD, MBA, Jonas Pettersson, MD, PhD, Anita E. Melgaard, MSc, Friedeborg Seitz, MD, Anders Valeur, PhD, Stine Just Maarbjerg, PhD
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Current Therapeutic Research
Subjects:
Cardiac repolarization
Concentration-QTc analysis
Dasiglucagon
Pharmacokinetics
Online Access:http://www.sciencedirect.com/science/article/pii/S0011393X22000078

Internet

http://www.sciencedirect.com/science/article/pii/S0011393X22000078

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