Hypercontractile cardiac phenotype in mice overexpressing the regulatory subunit PR72 of protein phosphatase 2A

Hypercontractile cardiac phenotype in mice overexpressing the regulatory subunit PR72 of protein phosphatase 2A

BackgroundThe activity, localization, and substrate specificity of the protein phosphatase 2A (PP2A) heterotrimer are controlled by various regulatory B subunits. PR72 belongs to the B'' gene family and has been shown to be upregulated in human heart failure. However, little is known about...

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Bibliographic Details
Main Authors: Julius R. Herting, Jule H. König, Katarina Hadova, Alexander Heinick, Frank U. Müller, Paul Pauls, Matthias D. Seidl, Carolina Soppa, Uwe Kirchhefer
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
protein phosphatase 2A
regulatory B'' subunit PPP2R3A/PR72
contractility
Ca2+ handling
protein phosphorylation
Na+/Ca2+ exchanger
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2023.1239555/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2023.1239555/full

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