Transcriptomic analysis of benznidazole-resistant and susceptible Trypanosoma cruzi populations

Transcriptomic analysis of benznidazole-resistant and susceptible Trypanosoma cruzi populations

Abstract Background Chagas disease (CD), caused by the parasite Trypanosoma cruzi, is a serious public health concern in Latin America. Nifurtimox and benznidazole (BZ), the only two drugs currently approved for the treatment of CD, have very low efficacies in the chronic phase of the disease and se...

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Main Authors: Davi Alvarenga Lima, Leilane Oliveira Gonçalves, João Luís Reis-Cunha, Paul Anderson Souza Guimarães, Jeronimo Conceição Ruiz, Daniel Barbosa Liarte, Silvane Maria Fonseca Murta
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Parasites & Vectors
Subjects:
RNAseq
Transcriptomics
Chagas disease
Trypanosoma cruzi
Resistance
Benznidazole
Online Access:https://doi.org/10.1186/s13071-023-05775-4

Internet

https://doi.org/10.1186/s13071-023-05775-4

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