Antitumor Effects and Delivery Profiles of Menahydroquinone-4 Prodrugs with Ionic or Nonionic Promoiety to Hepatocellular Carcinoma Cells

Antitumor Effects and Delivery Profiles of Menahydroquinone-4 Prodrugs with Ionic or Nonionic Promoiety to Hepatocellular Carcinoma Cells

Hepatocellular carcinoma (HCC) shows poor prognosis owing to its very frequent recurrence even after curative treatment. Thus, an effective and safe long-term chemopreventive agent is strongly in demand. Menahydroquinone-4 (MKH) is an active form of menaquinone-4 (MK-4, vitamin K2) that is involved...

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Bibliographic Details
Main Authors: Shuichi Setoguchi, Daisuke Watase, Kazuhisa Matsunaga, Hirofumi Yamakawa, Shotaro Goto, Kazuki Terada, Kenji Ohe, Munechika Enjoji, Yoshiharu Karube, Jiro Takata
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Molecules
Subjects:
prodrug
menahydroquinone-4
menaquinone-4
drug delivery system
hepatocellular carcinoma
Online Access:http://www.mdpi.com/1420-3049/23/7/1738

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http://www.mdpi.com/1420-3049/23/7/1738

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