Neuronal knockdown of Cullin3 as a Drosophila model of autism spectrum disorder

Neuronal knockdown of Cullin3 as a Drosophila model of autism spectrum disorder

Abstract Mutations in Cullin-3 (Cul3), a conserved gene encoding a ubiquitin ligase, are strongly associated with autism spectrum disorder (ASD). Here, we characterize ASD-related pathologies caused by neuron-specific Cul3 knockdown in Drosophila. We confirmed that neuronal Cul3 knockdown causes sho...

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Bibliographic Details
Main Authors: Samantha J. Tener, Zhi Lin, Scarlet J. Park, Kairaluchi Oraedu, Matthew Ulgherait, Emily Van Beek, Andrés Martínez-Muñiz, Meghan Pantalia, Jared A. Gatto, Julia Volpi, Nicholas Stavropoulos, William W. Ja, Julie C. Canman, Mimi Shirasu-Hiza
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-51657-9

Internet

https://doi.org/10.1038/s41598-024-51657-9

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