Quantitative Analysis of the Potency of Equimolar Two-Drug Combinations and Combi-Molecules Involving Kinase Inhibitors In Vitro: The Concept of Balanced Targeting

Quantitative Analysis of the Potency of Equimolar Two-Drug Combinations and Combi-Molecules Involving Kinase Inhibitors In Vitro: The Concept of Balanced Targeting

The median-effect principle proposed by Chou and Talalay is the most effective approach to parameterize interactions between several agents in combination. However, this method cannot be used to evaluate the effectiveness of equimolar drug combinations, which are comparative references for dual-targ...

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Bibliographic Details
Main Authors: Suman Rao, Benoît Thibault, Lisa Peyrard, Anne-Laure Larroque-Lombard, Martin Rupp, Cédric Thauvin, Bertrand J. Jean-Claude
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
equimolar combinations
hybrid molecules
combi-molecules
balanced targeting
kinase inhibitors
multi-targeting
Online Access:https://www.mdpi.com/1422-0067/22/17/9569

Internet

https://www.mdpi.com/1422-0067/22/17/9569

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