Development of a chromosomally integrated metabolite-inducible Leu3p-alpha-IPM "off-on" gene switch.

Development of a chromosomally integrated metabolite-inducible Leu3p-alpha-IPM "off-on" gene switch.

Present technology uses mostly chimeric proteins as regulators and hormones or antibiotics as signals to induce spatial and temporal gene expression.Here, we show that a chromosomally integrated yeast 'Leu3p-alpha-IotaRhoMu' system constitutes a ligand-inducible regulatory "off-on&quo...

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Bibliographic Details
Main Authors: Maria Poulou, Donald Bell, Kostas Bozonelos, Maria Alexiou, Anthony Gavalas, Robin Lovell-Badge, Eumorphia Remboutsika
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-08-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2930855?pdf=render

Internet

http://europepmc.org/articles/PMC2930855?pdf=render

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