Mechanism of action of disulfiram and research advances in anti-glomerular basement membrane type glomerulonephritis
Disulfiram is widely applied for treating chronic alcoholism. In recent years, researchers have proposed specific anti-cancer mechanisms by disulfiram, such as arresting the activity of acetaldehyde dehydrogenase （ALDH） and boosting intracellular reactive oxygen species （ROS）（reactive oxygen species...
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| Format: | Article |
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Editorial Department of Journal of Clinical Nephrology
2024-03-01
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| Series: | Linchuang shenzangbing zazhi |
| Subjects: | |
| Online Access: | http://www.lcszb.com/cn/article/doi/10.3969/j.issn.1671-2390.2024.03.011 |
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| author | Yan-yu Zhang Xin Lyu Xiao-guang Huang Xiao-jun Ren Xue Wang Wei-min Yu |
| author_facet | Yan-yu Zhang Xin Lyu Xiao-guang Huang Xiao-jun Ren Xue Wang Wei-min Yu |
| author_sort | Yan-yu Zhang |
| collection | DOAJ |
| description | Disulfiram is widely applied for treating chronic alcoholism. In recent years, researchers have proposed specific anti-cancer mechanisms by disulfiram, such as arresting the activity of acetaldehyde dehydrogenase （ALDH） and boosting intracellular reactive oxygen species （ROS）（reactive oxygen species）. A higher concentration of ROS suppressed the activity of nuclear factor kappa-B （NF-κB） and promoted the conjugation between ROS and nuclear protein localization protein 4 （nuclear protein localization protein 4）. Conjugation of NPL4, an inhibition of FROUNT protein and anti-cancer activity of disulfiram have been demonstrated in various cancer models. Anti-glomerular basement membrane glomerulonephritis is one type of acute glomerulonephritis. Upon a definite diagnosis, it should be promptly treated for relieving symptoms and improving outcomes. Disulfiram could antagonize C-C chemokine receptor type 2 and C-C chemokine receptor type 5 through suppressing C-C chemokine receptor type 2/C-C chemokine receptor type 5, CCR-2/CCR-5） and FROUNT protein interacted to suppress the migration, aggregation and activation of macrophages for alleviating anti-glomerular basement membrane type glomerulonephritis. It indicated that disulfiram had some potential therapeutic value. This review focused upon the molecular mechanism of disulfiram. And disulfiram may become a new agent for anti-glomerular basement membrane glomerulonephritis. |
| first_indexed | 2024-04-24T17:12:18Z |
| format | Article |
| id | doaj.art-03a12ba954aa4acea742d5b070c15910 |
| institution | Directory Open Access Journal |
| issn | 1671-2390 |
| language | zho |
| last_indexed | 2024-04-24T17:12:18Z |
| publishDate | 2024-03-01 |
| publisher | Editorial Department of Journal of Clinical Nephrology |
| record_format | Article |
| series | Linchuang shenzangbing zazhi |
| spelling | doaj.art-03a12ba954aa4acea742d5b070c159102024-03-28T09:00:08ZzhoEditorial Department of Journal of Clinical NephrologyLinchuang shenzangbing zazhi1671-23902024-03-0124324925310.3969/j.issn.1671-2390.2024.03.01120230084Mechanism of action of disulfiram and research advances in anti-glomerular basement membrane type glomerulonephritisYan-yu Zhang0Xin Lyu1Xiao-guang Huang2Xiao-jun Ren3Xue Wang4Wei-min Yu5Third Hospital, Shanxi Medical University (Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital), Taiyuan 030032, ChinaThird Hospital, Shanxi Medical University (Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital), Taiyuan 030032, ChinaThird Hospital, Shanxi Medical University (Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital), Taiyuan 030032, ChinaThird Hospital, Shanxi Medical University (Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital), Taiyuan 030032, ChinaThird Hospital, Shanxi Medical University (Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital), Taiyuan 030032, ChinaThird Hospital, Shanxi Medical University (Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital), Taiyuan 030032, ChinaDisulfiram is widely applied for treating chronic alcoholism. In recent years, researchers have proposed specific anti-cancer mechanisms by disulfiram, such as arresting the activity of acetaldehyde dehydrogenase （ALDH） and boosting intracellular reactive oxygen species （ROS）（reactive oxygen species）. A higher concentration of ROS suppressed the activity of nuclear factor kappa-B （NF-κB） and promoted the conjugation between ROS and nuclear protein localization protein 4 （nuclear protein localization protein 4）. Conjugation of NPL4, an inhibition of FROUNT protein and anti-cancer activity of disulfiram have been demonstrated in various cancer models. Anti-glomerular basement membrane glomerulonephritis is one type of acute glomerulonephritis. Upon a definite diagnosis, it should be promptly treated for relieving symptoms and improving outcomes. Disulfiram could antagonize C-C chemokine receptor type 2 and C-C chemokine receptor type 5 through suppressing C-C chemokine receptor type 2/C-C chemokine receptor type 5, CCR-2/CCR-5） and FROUNT protein interacted to suppress the migration, aggregation and activation of macrophages for alleviating anti-glomerular basement membrane type glomerulonephritis. It indicated that disulfiram had some potential therapeutic value. This review focused upon the molecular mechanism of disulfiram. And disulfiram may become a new agent for anti-glomerular basement membrane glomerulonephritis.http://www.lcszb.com/cn/article/doi/10.3969/j.issn.1671-2390.2024.03.011disulfiramanti-glomerular basement membrane glomerulonephritismacrophage |
| spellingShingle | Yan-yu Zhang Xin Lyu Xiao-guang Huang Xiao-jun Ren Xue Wang Wei-min Yu Mechanism of action of disulfiram and research advances in anti-glomerular basement membrane type glomerulonephritis Linchuang shenzangbing zazhi disulfiram anti-glomerular basement membrane glomerulonephritis macrophage |
| title | Mechanism of action of disulfiram and research advances in anti-glomerular basement membrane type glomerulonephritis |
| title_full | Mechanism of action of disulfiram and research advances in anti-glomerular basement membrane type glomerulonephritis |
| title_fullStr | Mechanism of action of disulfiram and research advances in anti-glomerular basement membrane type glomerulonephritis |
| title_full_unstemmed | Mechanism of action of disulfiram and research advances in anti-glomerular basement membrane type glomerulonephritis |
| title_short | Mechanism of action of disulfiram and research advances in anti-glomerular basement membrane type glomerulonephritis |
| title_sort | mechanism of action of disulfiram and research advances in anti glomerular basement membrane type glomerulonephritis |
| topic | disulfiram anti-glomerular basement membrane glomerulonephritis macrophage |
| url | http://www.lcszb.com/cn/article/doi/10.3969/j.issn.1671-2390.2024.03.011 |
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