Tracing Nutrient Flux Following Monocarboxylate Transporter-1 Inhibition with AZD3965

Tracing Nutrient Flux Following Monocarboxylate Transporter-1 Inhibition with AZD3965

The monocarboxylate transporter 1 (MCT1) is a key element in tumor cell metabolism and inhibition of MCT1 with AZD3965 is undergoing clinical trials. We aimed to investigate nutrient fluxes associated with MCT1 inhibition by AZD3965 to identify possible biomarkers of drug action. We synthesized an &...

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Bibliographic Details
Main Authors: Marta Braga, Maciej Kaliszczak, Laurence Carroll, Zachary T. Schug, Kathrin Heinzmann, Nicoleta Baxan, Adrian Benito, Gabriel N. Valbuena, Stephen Stribbling, Alice Beckley, Gillian Mackay, Francesco Mauri, John Latigo, Chris Barnes, Hector Keun, Eyal Gottlieb, Eric O. Aboagye
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Cancers
Subjects:
monocarboxylate transporter 1
cancer metabolism
lactate
glycolysis
AZD3965
diffuse large B-cell lymphoma
Online Access:https://www.mdpi.com/2072-6694/12/6/1703

Internet

https://www.mdpi.com/2072-6694/12/6/1703

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