Respiratory syncytial virus co-opts hypoxia-inducible factor-1α-mediated glycolysis to favor the production of infectious virus

Respiratory syncytial virus co-opts hypoxia-inducible factor-1α-mediated glycolysis to favor the production of infectious virus

ABSTRACT Glycolysis, a series of oxidative reactions used to metabolize glucose and provide energy to host cells, is also required for respiratory syncytial virus (RSV) infection. However, the role of glycolysis during RSV infection and its underlying molecular mechanisms remain to be further explor...

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Bibliographic Details
Main Authors: Li-Feng Chen, Jun-Xing Cai, Jing-Jing Zhang, Yu-Jun Tang, Jia-Yi Chen, Si Xiong, Yao-Lan Li, Hong Zhang, Zhong Liu, Man-Mei Li
Format: Article
Language:English
Published: American Society for Microbiology 2023-10-01
Series:mBio
Subjects:
respiratory syncytial virus
HIF-1α
glycolysis
IR-PI3K-Akt signaling
mitochondria
ROS
Online Access:https://journals.asm.org/doi/10.1128/mbio.02110-23

Internet

https://journals.asm.org/doi/10.1128/mbio.02110-23

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