Comprehensive Analysis of MEN1 Mutations and Their Role in Cancer
MENIN is a scaffold protein encoded by the MEN1 gene that functions in multiple biological processes, including cell proliferation, migration, gene expression, and DNA damage repair. MEN1 is a tumor suppressor gene, and mutations that disrupts MEN1 function are common to many tumor types. Mutations...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/12/9/2616 |
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| author | Devi D. Nelakurti Amrit L. Pappula Swetha Rajasekaran Wayne O. Miles Ruben C. Petreaca |
| author_facet | Devi D. Nelakurti Amrit L. Pappula Swetha Rajasekaran Wayne O. Miles Ruben C. Petreaca |
| author_sort | Devi D. Nelakurti |
| collection | DOAJ |
| description | MENIN is a scaffold protein encoded by the MEN1 gene that functions in multiple biological processes, including cell proliferation, migration, gene expression, and DNA damage repair. MEN1 is a tumor suppressor gene, and mutations that disrupts MEN1 function are common to many tumor types. Mutations within MEN1 may also be inherited (germline). Many of these inherited mutations are associated with a number of pathogenic syndromes of the parathyroid and pancreas, and some also predispose patients to hyperplasia. In this study, we cataloged the reported germline mutations from the ClinVar database and compared them with the somatic mutations detected in cancers from the Catalogue of Somatic Mutations in Cancer (COSMIC) database. We then used statistical software to determine the probability of mutations being pathogenic or driver. Our data show that many confirmed germline mutations do not appear in tumor samples. Thus, most mutations that disable MEN1 function in tumors are somatic in nature. Furthermore, of the germline mutations that do appear in tumors, only a fraction has the potential to be pathogenic or driver mutations. |
| first_indexed | 2024-03-10T16:21:08Z |
| format | Article |
| id | doaj.art-03a180b5ca864d0fbea1d127054d46fd |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T16:21:08Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-03a180b5ca864d0fbea1d127054d46fd2023-11-20T13:37:58ZengMDPI AGCancers2072-66942020-09-01129261610.3390/cancers12092616Comprehensive Analysis of MEN1 Mutations and Their Role in CancerDevi D. Nelakurti0Amrit L. Pappula1Swetha Rajasekaran2Wayne O. Miles3Ruben C. Petreaca4Biomedical Science Undergraduate Program, The Ohio State University Medical School, Columbus, OH 43210, USAComputer Science and Engineering Undergraduate Program, The Ohio State University, Columbus, OH 43210, USADepartment of Molecular Genetics, The Ohio State University, Columbus, OH 43210, USADepartment of Cancer Biology and Genetics, The Ohio State University Medical School, Columbus, OH 43210, USADepartment of Molecular Genetics, The Ohio State University, Marion, OH 43302, USAMENIN is a scaffold protein encoded by the MEN1 gene that functions in multiple biological processes, including cell proliferation, migration, gene expression, and DNA damage repair. MEN1 is a tumor suppressor gene, and mutations that disrupts MEN1 function are common to many tumor types. Mutations within MEN1 may also be inherited (germline). Many of these inherited mutations are associated with a number of pathogenic syndromes of the parathyroid and pancreas, and some also predispose patients to hyperplasia. In this study, we cataloged the reported germline mutations from the ClinVar database and compared them with the somatic mutations detected in cancers from the Catalogue of Somatic Mutations in Cancer (COSMIC) database. We then used statistical software to determine the probability of mutations being pathogenic or driver. Our data show that many confirmed germline mutations do not appear in tumor samples. Thus, most mutations that disable MEN1 function in tumors are somatic in nature. Furthermore, of the germline mutations that do appear in tumors, only a fraction has the potential to be pathogenic or driver mutations.https://www.mdpi.com/2072-6694/12/9/2616pancreatic cancerparathyroid cancermutational signatures |
| spellingShingle | Devi D. Nelakurti Amrit L. Pappula Swetha Rajasekaran Wayne O. Miles Ruben C. Petreaca Comprehensive Analysis of MEN1 Mutations and Their Role in Cancer Cancers pancreatic cancer parathyroid cancer mutational signatures |
| title | Comprehensive Analysis of MEN1 Mutations and Their Role in Cancer |
| title_full | Comprehensive Analysis of MEN1 Mutations and Their Role in Cancer |
| title_fullStr | Comprehensive Analysis of MEN1 Mutations and Their Role in Cancer |
| title_full_unstemmed | Comprehensive Analysis of MEN1 Mutations and Their Role in Cancer |
| title_short | Comprehensive Analysis of MEN1 Mutations and Their Role in Cancer |
| title_sort | comprehensive analysis of men1 mutations and their role in cancer |
| topic | pancreatic cancer parathyroid cancer mutational signatures |
| url | https://www.mdpi.com/2072-6694/12/9/2616 |
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