p53 accelerates endothelial cell senescence in diabetic retinopathy by enhancing FoxO3a ubiquitylation and degradation via UBE2L6

p53 accelerates endothelial cell senescence in diabetic retinopathy by enhancing FoxO3a ubiquitylation and degradation via UBE2L6

Diabetic retinopathy (DR) is the most common ocular fundus disease in diabetic patients. Chronic hyperglycemia not only promotes the development of diabetes and its complications, but also aggravates the occurrence of senescence. Previous studies have shown that DR is associated with senescence, but...

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Bibliographic Details
Main Authors: Ying Cheng, Man Zhang, Rong Xu, Lingli Fu, Mei Xue, Chaofei Xu, Chao Tang, Ting Fang, Xiaohuan Liu, Bei Sun, Liming Chen
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Experimental Gerontology
Subjects:
Diabetic retinopathy
Senescence
Single-cell RNA sequencing
p53
Ubiquitination
Online Access:http://www.sciencedirect.com/science/article/pii/S0531556524000330

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http://www.sciencedirect.com/science/article/pii/S0531556524000330

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