Development of a Combined Lipid-Based Nanoparticle Formulation for Enhanced siRNA Delivery to Vascular Endothelial Cells

Development of a Combined Lipid-Based Nanoparticle Formulation for Enhanced siRNA Delivery to Vascular Endothelial Cells

Low transfection efficiency in endothelial cells (EC) is still a bottleneck for the majority of siRNA-based vascular delivery approaches. In this work, we developed a lipid-based nanoparticle (LNP) formulation based on a combination of a permanently charged cationic lipid-DOTAP and a conditionally i...

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Bibliographic Details
Main Authors: Yutong He, Dongdong Bi, Josée A. Plantinga, Grietje Molema, Jeroen Bussmann, Jan A. A. M. Kamps
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Pharmaceutics
Subjects:
lipid-based nanoparticles
cationic lipid formulation
endothelial cell delivery
siRNA therapy
zebrafish model
Online Access:https://www.mdpi.com/1999-4923/14/10/2086

Internet

https://www.mdpi.com/1999-4923/14/10/2086

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