Autoantibodies in Serum of Systemic Scleroderma Patients: Peptide-Based Epitope Mapping Indicates Increased Binding to Cytoplasmic Domains of CXCR3

Autoantibodies in Serum of Systemic Scleroderma Patients: Peptide-Based Epitope Mapping Indicates Increased Binding to Cytoplasmic Domains of CXCR3

Systemic sclerosis (SSc) is a severe chronic autoimmune disease with high morbidity and mortality. Sera of patients with SSc contain a large variety of autoantibody (aab) reactivities. Among these are functionally active aab that bind to G protein-coupled receptors (GPCR) such as C-X-C motif chemoki...

Full description

Bibliographic Details
Main Authors: Andreas Recke, Ann-Katrin Regensburger, Florian Weigold, Antje Müller, Harald Heidecke, Gabriele Marschner, Christoph M. Hammers, Ralf J. Ludwig, Gabriela Riemekasten
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Immunology
Subjects:
autoantibodies
CXCR3
peptide array
systemic sclerosis
G protein-coupled receptor
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00428/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00428/full

Similar Items