Purkinje-cell-specific MeCP2 deficiency leads to motor deficits and autistic-like behavior due to aberrations in PTP1B-TrkB-SK signaling

Purkinje-cell-specific MeCP2 deficiency leads to motor deficits and autistic-like behavior due to aberrations in PTP1B-TrkB-SK signaling

Summary: Patients with Rett syndrome suffer from a loss-of-function mutation of the Mecp2 gene, which results in various symptoms including autistic traits and motor deficits. Deletion of Mecp2 in the brain mimics part of these symptoms, but the specific function of methyl-CpG-binding protein 2 (MeC...

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Bibliographic Details
Main Authors: Fang-Xiao Xu, Xin-Tai Wang, Xin-Yu Cai, Jia-Yu Liu, Jing-Wen Guo, Fan Yang, Wei Chen, Martijn Schonewille, Chris De Zeeuw, Lin Zhou, Ying Shen
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Cell Reports
Subjects:
CP: Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723015711

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http://www.sciencedirect.com/science/article/pii/S2211124723015711

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