The Binding of <i>Alpinia galanga</i> Oil and Its Nanoemulsion to Mammal GABA<sub>A</sub> Receptors Using Rat Cortical Membranes and an In Silico Modeling Platform

The Binding of <i>Alpinia galanga</i> Oil and Its Nanoemulsion to Mammal GABA<sub>A</sub> Receptors Using Rat Cortical Membranes and an In Silico Modeling Platform

The anesthetic effect of <i>Alpinia galanga</i> oil (AGO) has been reported. However, knowledge of its pathway in mammals is limited. In the present study, the binding of AGO and its key compounds, methyl eugenol, 1,8-cineole, and 4-allylphenyl acetate, to gamma-aminobutyric acid type A...

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Bibliographic Details
Main Authors: Nattakanwadee Khumpirapang, Krit Suknuntha, Pathomwat Wongrattanakamon, Supat Jiranusornkul, Songyot Anuchapreeda, Petrine Wellendorph, Anette Müllertz, Thomas Rades, Siriporn Okonogi
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Pharmaceutics
Subjects:
<i>Alpinia galanga</i>
essential oil
mammal anesthesia
anesthetic pathway
positive allosteric modulation
binding assay
Online Access:https://www.mdpi.com/1999-4923/14/3/650

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https://www.mdpi.com/1999-4923/14/3/650

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