Extracellular vesicle-packaged circBIRC6 from cancer-associated fibroblasts induce platinum resistance via SUMOylation modulation in pancreatic cancer

Extracellular vesicle-packaged circBIRC6 from cancer-associated fibroblasts induce platinum resistance via SUMOylation modulation in pancreatic cancer

Abstract Background Cancer-associated fibroblasts (CAFs) play pivotal roles in chemoresistance of pancreatic ductal adenocarcinoma (PDAC). However, the underlying mechanisms are poorly understood. Revealing the cross-talk network between tumor stroma and pancreatic cancer and developing effective st...

Full description

Bibliographic Details
Main Authors: Shangyou Zheng, Qing Tian, Yuan Yuan, Shuxin Sun, Tingting Li, Renpeng Xia, Rihua He, Yuming Luo, Qing Lin, Zhiqiang Fu, Yu Zhou, Rufu Chen, Chonghui Hu
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Extracellular vesicles
Cancer-associated fibroblasts
Circular RNAs
Non-homologous end joining
SUMOylation
Oxaliplatin resistance.
Online Access:https://doi.org/10.1186/s13046-023-02854-3

Internet

https://doi.org/10.1186/s13046-023-02854-3

Similar Items