Continuous gas/liquid–liquid/liquid flow synthesis of 4-fluoropyrazole derivatives by selective direct fluorination

Continuous gas/liquid–liquid/liquid flow synthesis of 4-fluoropyrazole derivatives by selective direct fluorination

4-Fluoropyrazole systems may be prepared by a single, sequential telescoped two-step continuous gas/liquid–liquid/liquid flow process from diketone, fluorine gas and hydrazine starting materials.

Bibliographic Details
Main Authors: Jessica R. Breen, Graham Sandford, Dmitrii S. Yufit, Judith A. K. Howard, Jonathan Fray, Bhairavi Patel
Format: Article
Language:English
Published: Beilstein-Institut 2011-08-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
continuous flow reactions
fluorine
fluoropyrazole
gas-liquid flow reactor
selective direct fluorination
Online Access:https://doi.org/10.3762/bjoc.7.120

Internet

https://doi.org/10.3762/bjoc.7.120

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