Dual Blockade of TNF and IL-17A Inhibits Inflammation and Structural Damage in a Rat Model of Spondyloarthritis

Dual Blockade of TNF and IL-17A Inhibits Inflammation and Structural Damage in a Rat Model of Spondyloarthritis

The tumor necrosis factor (TNF) and IL-23/IL-17 axes are the main therapeutic targets in spondyloarthritis. Despite the clinical efficacy of blocking either pathway, monotherapy does not induce remission in all patients and its effect on new bone formation remains unclear. We aimed to study the effe...

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Bibliographic Details
Main Authors: Ihsan Hammoura, Renee H. Fiechter, Shaughn H. Bryant, Susan Westmoreland, Gillian Kingsbury, Wendy Waegell, Sander W. Tas, Dominique L. Baeten, Marleen G. H. van de Sande, Melissa N. van Tok, Leonie M. van Duivenvoorde
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:International Journal of Molecular Sciences
Subjects:
spondyloarthritis
anti-TNF treatment
anti-IL 17A treatment
dual blockade
new bone formation
animal disease model
Online Access:https://www.mdpi.com/1422-0067/23/2/859

Internet

https://www.mdpi.com/1422-0067/23/2/859

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