Are FGFR and IDH1-2 alterations a positive prognostic factor in intrahepatic cholangiocarcinoma? An unresolved issue
Despite representing some of the most common and investigated molecular changes in intrahepatic cholangiocarcinoma (iCCA), the prognostic role of FGFR and IDH1/2 alterations still remains an open question. In this review we provide a critical analysis of available literature data regarding this topi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1137510/full |
| _version_ | 1797840517930680320 |
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| author | Giovanni Brandi Giovanni Brandi Chiara Deiana Chiara Deiana Linda Galvani Linda Galvani Andrea Palloni Angela Dalia Ricci Alessandro Rizzo Simona Tavolari Simona Tavolari |
| author_facet | Giovanni Brandi Giovanni Brandi Chiara Deiana Chiara Deiana Linda Galvani Linda Galvani Andrea Palloni Angela Dalia Ricci Alessandro Rizzo Simona Tavolari Simona Tavolari |
| author_sort | Giovanni Brandi |
| collection | DOAJ |
| description | Despite representing some of the most common and investigated molecular changes in intrahepatic cholangiocarcinoma (iCCA), the prognostic role of FGFR and IDH1/2 alterations still remains an open question. In this review we provide a critical analysis of available literature data regarding this topic, underlining the strengths and pitfalls of each study reported. Despite the overall poor quality of current available studies, a general trend toward a better overall survival for FGFR2 rearrangements and, possibly, for FGFR2-3 alterations can be inferred. On the other hand, the positive prognostic role of IDH1/2 mutation seems much more uncertain. In this scenario, better designed clinical trials in these subsets of iCCA patients are needed in order to get definitive conclusions on this issue. |
| first_indexed | 2024-04-09T16:16:38Z |
| format | Article |
| id | doaj.art-03b603c9b12b41ae9ce0d5fb4ecb610c |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-09T16:16:38Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-03b603c9b12b41ae9ce0d5fb4ecb610c2023-04-24T04:27:43ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-04-011310.3389/fonc.2023.11375101137510Are FGFR and IDH1-2 alterations a positive prognostic factor in intrahepatic cholangiocarcinoma? An unresolved issueGiovanni Brandi0Giovanni Brandi1Chiara Deiana2Chiara Deiana3Linda Galvani4Linda Galvani5Andrea Palloni6Angela Dalia Ricci7Alessandro Rizzo8Simona Tavolari9Simona Tavolari10Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, ItalyDepartment of Medicine and Surgical Sciences, University of Bologna, Bologna, ItalyMedical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, ItalyDepartment of Medicine and Surgical Sciences, University of Bologna, Bologna, ItalyMedical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, ItalyDepartment of Medicine and Surgical Sciences, University of Bologna, Bologna, ItalyMedical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, ItalyMedical Oncology Unit, National Institute of Gastroenterology, “Saverio de Bellis” Research Hospital, Bari, ItalyIRCCS Istituto Tumori “Giovanni Paolo II” of Bari, Struttura Semplice Dipartimentale di Oncologia Medica per la Presa in Carico Globale del Paziente Oncologico “Don Tonino Bello”, Bari, ItalyMedical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, ItalyDepartment of Medicine and Surgical Sciences, University of Bologna, Bologna, ItalyDespite representing some of the most common and investigated molecular changes in intrahepatic cholangiocarcinoma (iCCA), the prognostic role of FGFR and IDH1/2 alterations still remains an open question. In this review we provide a critical analysis of available literature data regarding this topic, underlining the strengths and pitfalls of each study reported. Despite the overall poor quality of current available studies, a general trend toward a better overall survival for FGFR2 rearrangements and, possibly, for FGFR2-3 alterations can be inferred. On the other hand, the positive prognostic role of IDH1/2 mutation seems much more uncertain. In this scenario, better designed clinical trials in these subsets of iCCA patients are needed in order to get definitive conclusions on this issue.https://www.frontiersin.org/articles/10.3389/fonc.2023.1137510/fullFGFRIDHcholangiocarcinomaprognosismolecular alteration |
| spellingShingle | Giovanni Brandi Giovanni Brandi Chiara Deiana Chiara Deiana Linda Galvani Linda Galvani Andrea Palloni Angela Dalia Ricci Alessandro Rizzo Simona Tavolari Simona Tavolari Are FGFR and IDH1-2 alterations a positive prognostic factor in intrahepatic cholangiocarcinoma? An unresolved issue Frontiers in Oncology FGFR IDH cholangiocarcinoma prognosis molecular alteration |
| title | Are FGFR and IDH1-2 alterations a positive prognostic factor in intrahepatic cholangiocarcinoma? An unresolved issue |
| title_full | Are FGFR and IDH1-2 alterations a positive prognostic factor in intrahepatic cholangiocarcinoma? An unresolved issue |
| title_fullStr | Are FGFR and IDH1-2 alterations a positive prognostic factor in intrahepatic cholangiocarcinoma? An unresolved issue |
| title_full_unstemmed | Are FGFR and IDH1-2 alterations a positive prognostic factor in intrahepatic cholangiocarcinoma? An unresolved issue |
| title_short | Are FGFR and IDH1-2 alterations a positive prognostic factor in intrahepatic cholangiocarcinoma? An unresolved issue |
| title_sort | are fgfr and idh1 2 alterations a positive prognostic factor in intrahepatic cholangiocarcinoma an unresolved issue |
| topic | FGFR IDH cholangiocarcinoma prognosis molecular alteration |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1137510/full |
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