GRP78 expression in peripheral blood mononuclear cells is a new predictive marker for the benefit of taxanes in breast cancer neoadjuvant treatment

GRP78 expression in peripheral blood mononuclear cells is a new predictive marker for the benefit of taxanes in breast cancer neoadjuvant treatment

Abstract Background Breast cancer treatment is tailored to the specific cancer subtype. Often, systemic treatment is given prior to surgery. Chemotherapy induces significant endoplasmic reticulum (ER) stress-mediated cell death and upregulation of 78-kDa glucose-regulated protein (GRP78). We hypothe...

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Bibliographic Details
Main Authors: Annat Raiter, Julia Lipovetzki, Ido Lubin, Rinat Yerushalmi
Format: Article
Language:English
Published: BMC 2020-04-01
Series:BMC Cancer
Subjects:
GRP78 expression
Breast cancer
Neoadjuvant chemotherapy
Peripheral blood mononuclear cells
Interferon gamma
Online Access:http://link.springer.com/article/10.1186/s12885-020-06835-z

Internet

http://link.springer.com/article/10.1186/s12885-020-06835-z

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