Characterization of the Charge Heterogeneity of a Monoclonal Antibody That Binds to Both Cation Exchange and Anion Exchange Columns under the Same Binding Conditions

Characterization of the Charge Heterogeneity of a Monoclonal Antibody That Binds to Both Cation Exchange and Anion Exchange Columns under the Same Binding Conditions

Therapeutic antibodies play an important role in the public healthcare system to treat patients with a variety of diseases. Protein characterization using an array of analytical tools provides in-depth information for drug quality, safety, efficacy, and the further understanding of the molecule. A t...

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Bibliographic Details
Main Authors: Ming-Ching Hsieh, Jingming Zhang, Liangjie Tang, Cheng-Yen Huang, Yang Shen, Alice Matathia, Jun Qian, Babita Saxena Parekh
Format: Article
Language:English
Published: MDPI AG 2024-06-01
Series:Antibodies
Subjects:
charge heterogeneity
anion exchange
cation exchange
monoclonal antibody
chemical labeling
hydrogen–deuterium (H/D) exchange mass spectrometry
Online Access:https://www.mdpi.com/2073-4468/13/3/52

Internet

https://www.mdpi.com/2073-4468/13/3/52

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