Researches of calcium-activated chloride channel ANO1 intervening amyotrophic lateral sclerosis progression by activating EGFR and CaMKII signaling

Researches of calcium-activated chloride channel ANO1 intervening amyotrophic lateral sclerosis progression by activating EGFR and CaMKII signaling

Background: ANO1 is closely correlated with the activation of EGFR and CaMKII, while EGFR and CaMKII show low activation in amyotrophic lateral sclerosis (ALS) models. Therefore, we designed experiments to verify that ANO1 may play a protective role on motor neurons in ALS by activating EGFR and CaM...

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Bibliographic Details
Main Authors: Ying Wang, Weiwei Liang, Tianhang Wang, Chunting Zhang, Yueqing Yang, Chaohua Cong, Xudong Wang, Shuyu Wang, Di Wang, Di Huo, Hongyong Wang, Xiaoli Su, Xingli Tan, Honglin Feng
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Brain Research Bulletin
Subjects:
Anoctamin1
Epidermal growth factor receptor
Calmodulin-dependent protein kinase II
Amyotrophic lateral sclerosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0361923023002174

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http://www.sciencedirect.com/science/article/pii/S0361923023002174

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