Monoacylated Cellular Prion Proteins Reduce Amyloid-β-Induced Activation of Cytoplasmic Phospholipase A2 and Synapse Damage

Monoacylated Cellular Prion Proteins Reduce Amyloid-β-Induced Activation of Cytoplasmic Phospholipase A2 and Synapse Damage

Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by the accumulation of amyloid-β (Aβ) and the loss of synapses. Aggregation of the cellular prion protein (PrPC) by Aβ oligomers induced synapse damage in cultured neurons. PrPC is attached to membranes via a glycosylp...

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Bibliographic Details
Main Authors: Ewan West, Craig Osborne, William Nolan, Clive Bate
Format: Article
Language:English
Published: MDPI AG 2015-06-01
Series:Biology
Subjects:
Alzheimer’s disease
amyloid-β
glycosylphosphatidylinositols
prion
synapses
synaptophysin
Online Access:http://www.mdpi.com/2079-7737/4/2/367

Internet

http://www.mdpi.com/2079-7737/4/2/367

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