Agonist-selective activation of individual G-proteins by muscarinic receptors

Agonist-selective activation of individual G-proteins by muscarinic receptors

Abstract Selective activation of individual subtypes of muscarinic receptors is a promising way to safely alleviate a wide range of pathological conditions in the central nervous system and the periphery as well. The flexible G-protein interface of muscarinic receptors allows them to interact with s...

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Bibliographic Details
Main Authors: Dominik Nelic, Nikolai Chetverikov, Martina Hochmalová, Christina Diaz, Vladimír Doležal, John Boulos, Jan Jakubík, Kirill Martemyanov, Alena Janoušková-Randáková
Format: Article
Language:English
Published: Nature Portfolio 2024-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-60259-4

Internet

https://doi.org/10.1038/s41598-024-60259-4

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