Tempol Protects Against Acetaminophen Induced Acute Hepatotoxicity by Inhibiting Oxidative Stress and Apoptosis

Tempol Protects Against Acetaminophen Induced Acute Hepatotoxicity by Inhibiting Oxidative Stress and Apoptosis

Acetaminophen (APAP)-induced acute hepatotoxicity is the leading cause of drug-induced acute liver failure. The aim of this study was to evaluate the effects of 4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl (tempol) on the protection of APAP-induced hepatotoxicity in mice. Mice were pretreated with...

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Bibliographic Details
Main Authors: Zheng Ge, Chenyu Wang, Junjie Zhang, Xiwang Li, Junhong Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Physiology
Subjects:
acetaminophen
acute hepatotoxicity
tempol
oxidative stress
apoptosis
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.00660/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2019.00660/full

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