Chronic Administrations of Guanfacine on Mesocortical Catecholaminergic and Thalamocortical Glutamatergic Transmissions

Chronic Administrations of Guanfacine on Mesocortical Catecholaminergic and Thalamocortical Glutamatergic Transmissions

It has been established that the selective α2A adrenoceptor agonist guanfacine reduces hyperactivity and improves cognitive impairment in patients with attention-deficit/hyperactivity disorder (ADHD). The major mechanisms of guanfacine are considered to involve the activation of the postsynaptic α2A...

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Bibliographic Details
Main Authors: Kouji Fukuyama, Tomosuke Nakano, Takashi Shiroyama, Motohiro Okada
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
attention-deficit/hyperactivity disorder
guanfacine
dopamine
norepinephrine
L-glutamate
GABA
Online Access:https://www.mdpi.com/1422-0067/22/8/4122

Internet

https://www.mdpi.com/1422-0067/22/8/4122

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