Desmoplasia influenced recurrence of disease and mortality in stage III colorectal cancer within five years after surgery and adjuvant therapy
Background/Aims: In patients with colon cancer who undergo resection for potential cure, 40–60% have advanced locoregional disease (stage III). Those who are suitable for adjuvant treatment had a definite disease-free-survival benefit. The aim of the present study was to demonstrate whether the pres...
Main Authors: | , , , , , , , |
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Format: | Article |
Language: | English |
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Wolters Kluwer Medknow Publications
2017-01-01
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Series: | The Saudi Journal of Gastroenterology |
Subjects: | |
Online Access: | http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2017;volume=23;issue=1;spage=39;epage=44;aulast=Zippi |
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author | Maddalena Zippi Giorgio De Toma Giovanni Minervini Claudio Cassieri Roberta Pica Diodoro Colarusso Simon Stock Pietro Crispino |
author_facet | Maddalena Zippi Giorgio De Toma Giovanni Minervini Claudio Cassieri Roberta Pica Diodoro Colarusso Simon Stock Pietro Crispino |
author_sort | Maddalena Zippi |
collection | DOAJ |
description | Background/Aims: In patients with colon cancer who undergo resection for potential cure, 40–60% have advanced locoregional disease (stage III). Those who are suitable for adjuvant treatment had a definite disease-free-survival benefit. The aim of the present study was to demonstrate whether the presence of desmoplasia influenced the mortality rate of stage III colorectal cancer (CRC) within 5 years from the surgery and adjuvant therapy. Patients and Methods: Sixty-five patients with stage III CRC underwent resection and adjuvant therapy. Qualitative categorization of desmoplasia was obtained using Ueno's stromal CRC classification. Desmoplasia was related to mortality using Spearman correlation and stratified with other histological variables (inflammation, grading) that concurred to the major determinant of malignancy (venous invasion and lymph nodes) using the Chi-square test. Result: The 5-year survival rate was 65% and the relapse rate was 37%. The mortality rate in patients with immature desmoplasia was 86%, 27% in intermediate desmoplasia, and 0% in mature desmoplasia (Spearman correlation coefficient: −0.572,P= 0.05). Conclusion: Immature desmoplasia appears to be associated with disease recurrence and mortality in stage III CRC patients. |
first_indexed | 2024-12-20T12:32:59Z |
format | Article |
id | doaj.art-03d7548ee93d4a97943e2236a8f2b77c |
institution | Directory Open Access Journal |
issn | 1319-3767 1998-4049 |
language | English |
last_indexed | 2024-12-20T12:32:59Z |
publishDate | 2017-01-01 |
publisher | Wolters Kluwer Medknow Publications |
record_format | Article |
series | The Saudi Journal of Gastroenterology |
spelling | doaj.art-03d7548ee93d4a97943e2236a8f2b77c2022-12-21T19:40:40ZengWolters Kluwer Medknow PublicationsThe Saudi Journal of Gastroenterology1319-37671998-40492017-01-01231394410.4103/1319-3767.199114Desmoplasia influenced recurrence of disease and mortality in stage III colorectal cancer within five years after surgery and adjuvant therapyMaddalena ZippiGiorgio De TomaGiovanni MinerviniClaudio CassieriRoberta PicaDiodoro ColarussoSimon StockPietro CrispinoBackground/Aims: In patients with colon cancer who undergo resection for potential cure, 40–60% have advanced locoregional disease (stage III). Those who are suitable for adjuvant treatment had a definite disease-free-survival benefit. The aim of the present study was to demonstrate whether the presence of desmoplasia influenced the mortality rate of stage III colorectal cancer (CRC) within 5 years from the surgery and adjuvant therapy. Patients and Methods: Sixty-five patients with stage III CRC underwent resection and adjuvant therapy. Qualitative categorization of desmoplasia was obtained using Ueno's stromal CRC classification. Desmoplasia was related to mortality using Spearman correlation and stratified with other histological variables (inflammation, grading) that concurred to the major determinant of malignancy (venous invasion and lymph nodes) using the Chi-square test. Result: The 5-year survival rate was 65% and the relapse rate was 37%. The mortality rate in patients with immature desmoplasia was 86%, 27% in intermediate desmoplasia, and 0% in mature desmoplasia (Spearman correlation coefficient: −0.572,P= 0.05). Conclusion: Immature desmoplasia appears to be associated with disease recurrence and mortality in stage III CRC patients.http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2017;volume=23;issue=1;spage=39;epage=44;aulast=ZippiColorectal cancerdesmoplasiadisease recurrenceleucovorinmortality |
spellingShingle | Maddalena Zippi Giorgio De Toma Giovanni Minervini Claudio Cassieri Roberta Pica Diodoro Colarusso Simon Stock Pietro Crispino Desmoplasia influenced recurrence of disease and mortality in stage III colorectal cancer within five years after surgery and adjuvant therapy The Saudi Journal of Gastroenterology Colorectal cancer desmoplasia disease recurrence leucovorin mortality |
title | Desmoplasia influenced recurrence of disease and mortality in stage III colorectal cancer within five years after surgery and adjuvant therapy |
title_full | Desmoplasia influenced recurrence of disease and mortality in stage III colorectal cancer within five years after surgery and adjuvant therapy |
title_fullStr | Desmoplasia influenced recurrence of disease and mortality in stage III colorectal cancer within five years after surgery and adjuvant therapy |
title_full_unstemmed | Desmoplasia influenced recurrence of disease and mortality in stage III colorectal cancer within five years after surgery and adjuvant therapy |
title_short | Desmoplasia influenced recurrence of disease and mortality in stage III colorectal cancer within five years after surgery and adjuvant therapy |
title_sort | desmoplasia influenced recurrence of disease and mortality in stage iii colorectal cancer within five years after surgery and adjuvant therapy |
topic | Colorectal cancer desmoplasia disease recurrence leucovorin mortality |
url | http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2017;volume=23;issue=1;spage=39;epage=44;aulast=Zippi |
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