Desmoplasia influenced recurrence of disease and mortality in stage III colorectal cancer within five years after surgery and adjuvant therapy

Background/Aims: In patients with colon cancer who undergo resection for potential cure, 40–60% have advanced locoregional disease (stage III). Those who are suitable for adjuvant treatment had a definite disease-free-survival benefit. The aim of the present study was to demonstrate whether the pres...

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Main Authors: Maddalena Zippi, Giorgio De Toma, Giovanni Minervini, Claudio Cassieri, Roberta Pica, Diodoro Colarusso, Simon Stock, Pietro Crispino
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2017-01-01
Series:The Saudi Journal of Gastroenterology
Subjects:
Online Access:http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2017;volume=23;issue=1;spage=39;epage=44;aulast=Zippi
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author Maddalena Zippi
Giorgio De Toma
Giovanni Minervini
Claudio Cassieri
Roberta Pica
Diodoro Colarusso
Simon Stock
Pietro Crispino
author_facet Maddalena Zippi
Giorgio De Toma
Giovanni Minervini
Claudio Cassieri
Roberta Pica
Diodoro Colarusso
Simon Stock
Pietro Crispino
author_sort Maddalena Zippi
collection DOAJ
description Background/Aims: In patients with colon cancer who undergo resection for potential cure, 40–60% have advanced locoregional disease (stage III). Those who are suitable for adjuvant treatment had a definite disease-free-survival benefit. The aim of the present study was to demonstrate whether the presence of desmoplasia influenced the mortality rate of stage III colorectal cancer (CRC) within 5 years from the surgery and adjuvant therapy. Patients and Methods: Sixty-five patients with stage III CRC underwent resection and adjuvant therapy. Qualitative categorization of desmoplasia was obtained using Ueno's stromal CRC classification. Desmoplasia was related to mortality using Spearman correlation and stratified with other histological variables (inflammation, grading) that concurred to the major determinant of malignancy (venous invasion and lymph nodes) using the Chi-square test. Result: The 5-year survival rate was 65% and the relapse rate was 37%. The mortality rate in patients with immature desmoplasia was 86%, 27% in intermediate desmoplasia, and 0% in mature desmoplasia (Spearman correlation coefficient: −0.572,P= 0.05). Conclusion: Immature desmoplasia appears to be associated with disease recurrence and mortality in stage III CRC patients.
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spelling doaj.art-03d7548ee93d4a97943e2236a8f2b77c2022-12-21T19:40:40ZengWolters Kluwer Medknow PublicationsThe Saudi Journal of Gastroenterology1319-37671998-40492017-01-01231394410.4103/1319-3767.199114Desmoplasia influenced recurrence of disease and mortality in stage III colorectal cancer within five years after surgery and adjuvant therapyMaddalena ZippiGiorgio De TomaGiovanni MinerviniClaudio CassieriRoberta PicaDiodoro ColarussoSimon StockPietro CrispinoBackground/Aims: In patients with colon cancer who undergo resection for potential cure, 40–60% have advanced locoregional disease (stage III). Those who are suitable for adjuvant treatment had a definite disease-free-survival benefit. The aim of the present study was to demonstrate whether the presence of desmoplasia influenced the mortality rate of stage III colorectal cancer (CRC) within 5 years from the surgery and adjuvant therapy. Patients and Methods: Sixty-five patients with stage III CRC underwent resection and adjuvant therapy. Qualitative categorization of desmoplasia was obtained using Ueno's stromal CRC classification. Desmoplasia was related to mortality using Spearman correlation and stratified with other histological variables (inflammation, grading) that concurred to the major determinant of malignancy (venous invasion and lymph nodes) using the Chi-square test. Result: The 5-year survival rate was 65% and the relapse rate was 37%. The mortality rate in patients with immature desmoplasia was 86%, 27% in intermediate desmoplasia, and 0% in mature desmoplasia (Spearman correlation coefficient: −0.572,P= 0.05). Conclusion: Immature desmoplasia appears to be associated with disease recurrence and mortality in stage III CRC patients.http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2017;volume=23;issue=1;spage=39;epage=44;aulast=ZippiColorectal cancerdesmoplasiadisease recurrenceleucovorinmortality
spellingShingle Maddalena Zippi
Giorgio De Toma
Giovanni Minervini
Claudio Cassieri
Roberta Pica
Diodoro Colarusso
Simon Stock
Pietro Crispino
Desmoplasia influenced recurrence of disease and mortality in stage III colorectal cancer within five years after surgery and adjuvant therapy
The Saudi Journal of Gastroenterology
Colorectal cancer
desmoplasia
disease recurrence
leucovorin
mortality
title Desmoplasia influenced recurrence of disease and mortality in stage III colorectal cancer within five years after surgery and adjuvant therapy
title_full Desmoplasia influenced recurrence of disease and mortality in stage III colorectal cancer within five years after surgery and adjuvant therapy
title_fullStr Desmoplasia influenced recurrence of disease and mortality in stage III colorectal cancer within five years after surgery and adjuvant therapy
title_full_unstemmed Desmoplasia influenced recurrence of disease and mortality in stage III colorectal cancer within five years after surgery and adjuvant therapy
title_short Desmoplasia influenced recurrence of disease and mortality in stage III colorectal cancer within five years after surgery and adjuvant therapy
title_sort desmoplasia influenced recurrence of disease and mortality in stage iii colorectal cancer within five years after surgery and adjuvant therapy
topic Colorectal cancer
desmoplasia
disease recurrence
leucovorin
mortality
url http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2017;volume=23;issue=1;spage=39;epage=44;aulast=Zippi
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